Endocytosis at the synaptic terminal
نویسندگان
چکیده
منابع مشابه
Clathrin-mediated endocytosis at the synaptic terminal: bridging the gap between physiology and molecules.
It has long been known that the maintenance of fast communication between neurons requires that presynaptic terminals recycle the small vesicles from which neurotransmitter is released. But the mechanisms that retrieve vesicles from the cell surface are still not understood. Although we have a wealth of information about the molecular details of endocytosis in non-neuronal cells, it is clear th...
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The supply of synaptic vesicles in the nerve terminal is maintained by a temporally linked balance of exo- and endocytosis. Tetanus and botulinum neurotoxins block neurotransmitter release by the enzymatic cleavage of proteins identified as critical for synaptic vesicle exocytosis. We show here that botulinum neurotoxin A is unique in that the toxin-induced block in exocytosis does not arrest v...
متن کاملCoordination of endocytosis at the synaptic periactive zone
Neurons in the central nervous system communicate via specialized junctions called synapses. Neurotransmitter-filled vesicles are clustered at these junctions, where they are released in response to synaptic activity. To sustain reliable neurotransmission the synaptic vesicles are recycled locally. At least two recycling mechanisms, bulk and clathrin-mediated endocytosis, occur in a region adja...
متن کاملEndocytosis of synaptic vesicle membrane at the frog neuromuscular junction
Frog nerve-muscle preparations were quick-frozen at various times after a single electrical stimulus in the presence of 4-aminopyridine (4-AP), after which motor nerve terminals were visualized by freeze-fracture. Previous studies have shown that such stimulation causes prompt discharge of 3,000-6,000 synaptic vesicles from each nerve terminal and, as a result, adds a large amount of synaptic v...
متن کاملSynaptic vesicle endocytosis at a CNS nerve terminal: faster kinetics at physiological temperatures and increased endocytotic capacity during maturation.
Synaptic vesicle membrane must be quickly retrieved and recycled after copious exocytosis to limit the depletion of vesicle pools. The rate of endocytosis at the calyx of Held nerve terminal has been measured directly using membrane capacitance measurements from immature postnatal day P7-P10 rat pups at room temperature (RT: 23-24 degrees C). This rate has an average time constant of tens of se...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2003
ISSN: 0022-3751,1469-7793
DOI: 10.1113/jphysiol.2003.049221